|
KMID : 0869220140180020069
|
|
Journal of Korean Geriatric Psychiatry
2014 Volume.18 No. 2 p.69 ~ p.75
|
|
|
Alcohol Consumption as Risk Factor for Progression from Mild Cognitive Impairment to Dementia : A Clinical Research Center for Dementia of South Korea Study
|
|
Kim Jin-Young
Kim Sang-Ha
Myung Woo-Jae
Kang Hyo-Shin
Na Duk-Lyul
Kim Seong-Yoon
Lee Jae-Hong
Han Seol-Heui
Choi Seong-Hye
Kim Sang-Yun
Kim Doh-Kwan
|
|
|
Abstract
|
|
|
Objective：Patients with mild cognitive impairment (MCI) are at high risk for dementia. Excessive alcohol consumption is known to adversely affect cognitive function. This study aimed to investigate the relationship between alcohol consumption and the risk for dementia in a cohort of MCI patients.
Methods：Participants (n=416) with (MCI) who met Petersen’s criteria were recruited from a nationwide, prospective cohort study of dementia and were followed for a median of 17.52 months (range 5.4-63.48). Alcohol consumption was evaluated at baseline.
Results：One hundred twenty seven individuals (30.5%) developed incident dementia (115 Alzheimer disease) during follow-up. Patients with current alcohol consumption at baseline had a higher rate of progression to Alzheimer’s dementia than those without current alcohol consumption (hazard ratio 1.61 ; 95% confidence interval 1.03 to 2.53).
Conclusion：Alcohol consumption may increase the risk of progression to Alzheimer’s dementia in patients with MCI.
|
|
|
KEYWORD
|
|
|
Alzheimer disease, Alcohol, Mild cognitive impairment
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|